This study was aimed to evaluate the protective effects of fucoidan on lysosomal enzymes in isoproterenol induced\nmyocardial infarcted rats. Male albino Wistar rats were pretreated with fucoidan (150 mg/kg body weight) daily for a period of\n14 days. After the pretreatment period, isoproterenol (100 mg/kg body weight) was subcutaneously injected into rats twice at\nan interval of 24 h to induce myocardial infarction. The activities of lysosomal enzymes (�²-glucuronidase, �²-galactosidase,\ncathepsin-B and D) were increased significantly (P<0.05) in the serum and heart of isoproterenol induced myocardial infarcted\nrats. Isoproterenol also decreased the activities of �²-glucuronidase and cathepsin-D in lysosomal fractions and enhanced in\ncytosolic fractions. The activities of antioxidant enzymes were decreased significantly (P<0.05) in isoproterenol induced\nmyocardial infarcted rats. Pretreatment with fucoidan (150 mg/kg body weight) showed significant (P<0.05) protective effects\non lysosomal glycohydrolases and cathepsins in isoproterenol induced myocardial infarcted rats. Thus, the results of study\nreveal that fucoidan minimizes isoproterenol induced myocardial damage by reinstating the activities of lysosomal enzymes to\nnormal levels. The observed effects were due to the membrane stabilizing and antioxidant properties of fucoidan.
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